Following a house fire in 2007, Paul left the USA for Berlin to do "something involving art". With no plan and just a suitcase to his name, over time he got involved with a handful of expatriate comedians to form one of Berlin's first English comedy showcases, the legendary Comedy in S.I.N. (2009-2013).

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Following a few years of dabbling in film and theater while working days as a graphic designer, in 2012 Paul quit work and became a full-time comedian. He's since performed is both a headliner and an emcee/compere all over Europe, including regular appearances in Germany, Austria, Belgium, Luxembourg, and the Netherlands as well as Finland, Norway, Poland, France, Czech Republic, Italy, Denmark, Estonia, Switzerland, Croatia, and Serbia.

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Since 2012 Paul has also hosted the weekly open mic "We Are Not Gemüsed" (along with his comedy partner Caroline Clifford), one of the longest-running and most popular English open mics in continental Europe. The show has played host to the likes of Kate Berlant, SNL's Brooks Whelan, Matt Koff of The Daily Show, Eddie Izzard opener Yacine Belhousse, and well-known German acts like Vincent Pfäfflin and Stefan Danziger.

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In early 2016 Paul was connected with German TV presenter Jan Böhmermann through a mutual friend to help the latter with his English, which soon led to the spontaneous decision to book Paul as the warm-up comedian for Jan's weekly "Neo Magazine Royale" in Cologne.

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A rampant experimentalist, Paul has produced all manner of shows in the lab-like atmosphere of Berlin, particularly at the Comedy Café Berlin. Show concepts have included the all-crowdwork show "Paul Salamone Works the Room", the high-tech solo sketch comedy of "Paul Salamone's Robot Suit", and the currently-running "How's Your German?" comedy game show.

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Paul currently lives in Berlin-Kreuzberg and has no cats.